study finds optimal dose for heart/circulatory effect with tocotrienolsn

Dose-dependent Modulation of Lipid Parameters, Cytokines and RNA by delta-tocotrienol in Hypercholesterolemic Subjects Restricted to AHA Step-1 Diet

We have already reported on this study, but we would now like to focus on the dosage. Various doses ranging from 125 to 750 mg per day have been tried.

The optimal values ​​​​in the blood parameters - including cholesterol - were in an amount of 250 mg/day tocotrienols. Only DMT3 tocotrienols from Annatto were used.

In the original: "The delta-tocotrienol plus AHA Step-1
thet caused reductions in lipid parameters in a dose-dependent manner with maximum effects on
serum total cholesterol (15%), LDL cholesterol (18%), triglycerides (14%) with 250 mg/d dose (P<
0.001). Doses above 500 mg/d resulted in induction in levels of all lipid parameters, except HDL-
cholesterol. The cytokines associated with cardiovascular disease (plasma TNF-alfa, IL-2, IL-4, IL-6,
IL-8, IL-10) were all down-regulated 39%-64% by delta-tocotrienol treatment (P < 0.01)."

Total cholesterol: (-15%; P < 0.001), LDL cholesterol (-18%; P < 0.001), triglycerides (-14%; P < 0.001).

proceed to Statins as cholesterol lowerers